Scientists have shown that the most common genetic cause of Parkinson's disease -- a mutant LRRK2 kinase enzyme -- contributes to the formation of inclusions in neurons, resembling one of the hallmark pathologies seen in Parkinson's disease. These inclusions are made up of aggregated alpha synuclein protein, which -- the research also shows -- can be prevented from forming by using two LRRK2 kinase inhibitor drugs now being developed for clinical use.
Scientists have shown that the most common genetic cause of Parkinson's disease -- a mutant LRRK2 kinase enzyme -- contributes to the formation of inclusions in neurons, resembling one of the hallmark pathologies seen in Parkinson's disease. These inclusions are made up of aggregated alpha synuclein protein, which -- the research also shows -- can be prevented from forming by using two LRRK2 kinase inhibitor drugs now being developed for clinical use.
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